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Metoprolol is widely distributed, it crosses the bloodbrain barrier, the placenta.The effects of Metoprolol on the fertility of human have not been studied.
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Although the efficacy of metoprolol beyond 3 months has not been conclusively established, data from studies with other beta-blockers suggest that metoprolol er tab should be continued for 1 to 3 years.Only 5% of the dose is excreted unmodified via the kidneys; in isolated cases, this figure can reach as high as 30% The elimination half-life of metoprolol averages 3.
hours with extremes of 1 and 9 hours Total clearance is approx.
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Plasma metoprolol concentrations attained after IV administration of the drug are approximately 2 times those attained following oral administration. Following IV metoprolol er tab of metoprolol over 10 minutes in healthy individuals, maximum β-adrenergic blocking activity occurred at 20 minutes.You will need to talk about the benefits and risks Use this medicine metoprolol extended-release tablets as ordered by your doctor.
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Patients with bronchospastic disease, t metoprolol, in general, not receive beta blockers, including T metoprolol. Because of its relative beta1 selectivity, however, Lopressor may be used in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment.Consider therapy modification Cholinergic Agonists: Beta-Blockers may t metoprolol the adverse/toxic effect of Cholinergic Agonists.
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Vagal maneuvers and/or IV adenosine are considered first-line interventions for the acute treatment of SVT and should be attempted prior to other therapies when clinically indicated; if such measures are ineffective or not feasible, an IV β-blocker may be considered in hemodynamically stable patients. Although evidence of efficacy is limited, experts state that the overall safety of β-adrenergic blockers warrants their use in patients with SVT.
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