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The half-life of hydroxybupropion is about 24 hours. In a limited number of geriatric patients with a major depressive episode, the apparent half-life of hydroxybupropion averaged about 34 hours after a single oral dose of the drug.Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder.

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Patients receiving bupropion should be advised to notify their clinician if they are taking or plan to take nonprescription over-the-counter or prescription drugs. The metabolism of bupropion and generic for wellbutrin xl 300 drugs might be affected by such concomitant use.However, it has been demonstrated in an antidepressant screening test in mice that hydroxybupropion is one-half as potent as bupropion, while threohydrobupropion and erythrohydrobupropion are 5-fold less potent than bupropion.

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Usually avoid combinations; use it only under special circumstances. Minimally clinically significant.Of the approximately 6000 patients studied in clinical trials of extended-release bupropion for smoking cessation or depression, 275 were 65 years of age or older, while 47 were 75 years of age and older.

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001, in Fig. Fig. b 2b The repeated ECS resulted in a significant anti-immobility effect as compared to the sham group p 0. 01 in both acute and subchronic studies vs.389/fphar. Thomas SJ, et al.

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Or ZYBAN. In the non-psychiatric cohort, neuropsychiatric adverse events of a serious nature were reported in 0.2005 Feb. -8.

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These results are clearly similar to the data for Wellbutrin XL listed above.Substance abusing patients are clearly another unique challenge. Other than opiate abusers, there is no absolute contraindication.

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