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( R )-(−)-citalopram (top), ( S )-(+)-citalopram (bottom)
Clinical data
Pronunciation/ s aɪ ˈ t æ l ə ˌ p r æ m, s ɪ -/ ; [2]
Trade namesCelexa, Cipramil, others (see below)
Pregnancy categoryUS: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classSelective serotonin reuptake inhibitor (SSRI) [1]
ATC codeN06AB04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability80% peak at 4 h [1]
MetabolismLiver (CYP3A4 and CYP2C19)
MetabolitesDesmethylcitalopram (DCT) and didesmethylcitalopram (DDCT)
Elimination half-life35 h
ExcretionMostly as unmetabolized citalopram, partly DCT and traces of DDCT in urine

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Decreased appetite and weight loss have been observed in association with the use of SSRIs.Celexa and other antidepressant medicines may cause serious estrogen and progesterone replacement effects, including: 1. Suicidal thoughts or actions: Celexa and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.

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Adverse sexual effects can be estrogen and progesterone replacement because there are several potentially overlapping etiologies, including sexual dysfunction associated with the underlying mood disorder.For Anxiety and Stress: I was diagnosed with panic disorder over a year ago and basically was a wreck. I couldn t drive, leave the house, even talk on the phone.

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The plasma protein binding is below 80% for citalopram and its main metabolites.Citalopram and demethylcitalopram are negligible inhibitors of CYP2C9, CYP2E1 and CYP3A4, and only weak inhibitors of CYP1A2, CYP2C19 and CYP2D6 as compared to other SSRIs established as significant inhibitors.

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IC. Noda Y, Daskalakis ZJ, Downar J, Croarkin PE, Fitzgerald PB, Blumberger DM. Neuropsychiatr Dis Treat.Medicines that estrogen and progesterone replacement with citalopram may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with citalopram.

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Zoloft is an estrogen progesterone ratio calculator antidepressant with less potential for drowsiness than many other antidepressants.Symptoms of withdrawal include: izziness, nxiety, ausea, omiting, ervousness, iarrhea, rritability, andinsomnia. he dose of Celexa and Cymbalta should be gradually reduced when therapy is discontinued to prevent symptoms of withdrawal.

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Ossible serious side effects of Lexapro include: erotonin syndromeSuicidal thinking and behaviorAbnormal bleedingSeizuresManic episodesConfusionHigh feverSlurred speechMuscle rigidityLow sodiumAngle closure glaucoma.I don t feel as depressed I feel even, grounded and no longer have the feeling that I am separated from myself.


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