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Doxepin
Clinical data
Trade namesSinequan, Quitaxon, Aponal, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa682390
License dataUS   FDA: Doxepin
Pregnancy categoryAU: C US: B (No risk in non-human studies)
Routes of administrationBy mouth, topical, intravenous, intramuscular injection [1]
Drug classTricyclic antidepressant (TCA)
ATC codeD04AX01 ( WHO ) N06AA12 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability13–45% (mean 29%) [5] [6]
Protein binding76% [7]
MetabolismHepatic (CYP2D6, CYP2C19) [4] [5]
MetabolitesNordoxepin, glucuronide conjugates [4]
Elimination half-lifeDoxepin: 8–24 hours (mean 17 hours) [7] Nordoxepin: 31 hours [7]
ExcretionUrine: ~50% [4] [5] Feces: minor [5]

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Levomilnacipran, mirtazapine, venlafaxine; NADRIs: bupropion; TCAs: amitriptyline, clomipramine, desipramine, doxepin , imipramine.: Definition of Treatment-Resistant Depression in the ... - CMS

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Doxepin other names goods:
  1. Adapin 25 mg
  2. Anten 75 mg
  3. Aponal 75 mg
  4. Deptran 75 mg
  5. Doneurin 10 mg
  6. Doxal 10 mg
  7. Doxépine 75 mg
  8. Doxepini 10 mg
  9. Doxepinum 75 mg
  10. Doxin 75 mg
  11. Espadox 75 mg
  12. Expan 10 mg
  13. Gilex 25 mg
  14. Ichderm 75 mg
  15. Mareen 10 mg
  16. Quitaxon 25 mg
  17. Sagalon 10 mg
  18. Silenor 10 mg
  19. Sinepin 75 mg
  20. Sinquan 10 mg
  21. Spectra 10 mg
  22. Triadapin 25 mg

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Antidepressants (Amitriptyline, Clomipramine, Desipramine, Doxepin , Mianserin, Trimipramine). One systematic review found limited evidence ...: Irritable Bowel Syndrome - Clinical Evidence Handbook ...

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Doxepin properties:

  • Doxepin all synonym: adapin, anten, aponal, deptran, doneurin, doxal, doxépine, doxepini, doxepinum, doxin, espadox, expan, gilex, ichderm, mareen, quitaxon, sagalon, silenor, sinepin, sinquan, spectra, triadapin, xepin, zonalon
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